Peer-reviewed veterinary case report
Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression.
- Journal:
- Behavioural brain research
- Year:
- 2018
- Authors:
- Hen-Shoval, D et al.
- Affiliation:
- Psychology Department
- Species:
- rodent
Abstract
BACKGROUND AND PURPOSE: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. EXPERIMENTAL APPROACH: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar-Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. KEY RESULTS: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). CONCLUSION AND IMPLICATIONS: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29860002/