Peer-reviewed veterinary case report
Absence of sibutramine effect on spontaneous anxiety in rats.
- Journal:
- Arquivos brasileiros de endocrinologia e metabologia
- Year:
- 2010
- Authors:
- Frassetto, Silvana S et al.
- Affiliation:
- Universidade Luterana do Brazil · Brazil
- Species:
- rodent
Abstract
UNLABELLED: INTRODUSTION: Sibutramine has been described as a drug recommended for treatment of obesity, since it has the ability to inhibit the reuptake of serotonin and noradrenaline in the central nervous system, thereby increasing energy expenditure. OBJECTIVE: Investigate the anxiogenic and anxiolytic effects of acute and chronic treatment with sibutramine in rats submitted to the task of the elevated plus-maze. METHODS: Diazepam was used as a positive control for the anxiolytic effect, and the task of the elevated plus-maze showed sensitivity to detect the effect. In the chronic treatment, sibutramine was ingested for a period of two months. RESULTS: The acute and chronic treatments at the studied dose, which is described to produce a maximum effect of anti-obesity in rats, did not interfere with anxiety. CONCLUSIONS: The acute and chronic administration of sibutramine is not related to anxiolytic or anxiogenic effects.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20625649/