Peer-reviewed veterinary case report
A reverse genetics approach to study feline infectious peritonitis.
- Journal:
- Journal of virology
- Year:
- 2012
- Authors:
- Tekes, Gergely et al.
- Affiliation:
- Institut fü · Germany
- Species:
- cat
Abstract
Feline infectious peritonitis (FIP) is a lethal immunopathological disease caused by feline coronaviruses (FCoVs). Here, we describe a reverse genetics approach to study FIP by assessing the pathogenicity of recombinant type I and type II and chimeric type I/type II FCoVs. All recombinant FCoVs established productive infection in cats, and recombinant type II FCoV (strain 79-1146) induced FIP. Virus sequence analyses from FIP-diseased cats revealed that the 3c gene stop codon of strain 79-1146 has changed to restore a full-length open reading frame (ORF).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22491466/