Peer-reviewed veterinary case report
A lethal mice model of recombinant vesicular stomatitis viruses for EBOV-targeting prophylactic vaccines evaluation.
- Journal:
- Virologica Sinica
- Year:
- 2024
- Authors:
- Zhang, Hong-Qing et al.
- Affiliation:
- Wuhan Institute of Virology · China
- Species:
- rodent
Abstract
• The recombinant VSV-EBOV is highly lethal to IFNα/β/γ Rmice. • The infected mice exhibit hyperviremia and distinct splenohepatic lesions. • Virus replicon particle vaccine can protect all IFNα/β/γ Rmice against VSV-EBOV lethal challenge. • This surrogate model can be used for EBOV vaccine evaluation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/38522616/