7-hydroxy flavones, isolated bioflavonoids, ameliorate LPS-induced AD via inhibition of the NFKB pathway.

Abstract

BACKGROUND: Neurodegenerative disorders and behavioural abnormalities, including learning and memory issues, are significantly influenced by infection and inflammation. We looked into how 7-hydroxyflavone affected a mouse model of learning and memory impairment brought on by LPS. OBJECTIVE: This investigational protocol aims to assess the impacts of 7HF on LPS-induced neuroinflammation and its impact on memory impairment in mice. METHODS: Mice were pretreated with 7HF (5, 10 mg/kg, po) and received LPS (250 µg/kg ip) for 7 days. The Morris water maze (MWM) and the NORT were used for assessing memory. In order to analyse the oxidative stress markers, biochemical assessments were performed after the mice were euthanised. Moreover, neuroinflammatory markers in the hippocampi of mouse brains, such as IL-6 and NFKB, were estimated. RESULTS: LPS administration led to decreased memory retention in both MWM and NORT, as a distinct rise in the oxidative stress, including lipid peroxidation (LPO) and reduction in glutathione (GSH) levels, was also observed. Moreover, reductions in IL-6 and NFKB levels were observed. Pretreatment of animals with 7HF reversed the LPS-induced behavioural and memory impairments, and it was also found to lower the IL-6 and NFKB levels in the hippocampus. CONCLUSION: This study demonstrates how 7HF has neuroprotective properties that help prevent memory loss and neuroinflammation brought on by LPS.